IDENTIFICATION       

Common name: Cartap

Other name: Cartap (BSI, E-ISO,（m）F-ISO,JMAF)/cartap hydrochloride

Iupac name: S, S’-(2-dimethylaminorimthylene) bis (thiocarbamate)

Chemical abstracts name:     S, S’-[2-(dimethylamino)-1, 3-propamediyl] dicarbamothioate

Type: Insecticide for Agriculture

CAS RN: [15263-53-3],[15263-52-2]

EEC No: 239-309-2

Development code: TI-1258

M.F.: C₇H₁₅N₃O₂S₂ / C₇H₁₆ CIN₃O₂S₂

Mol Wt: 237.3 / 273.8

 

Form (appearance): Colourless crystalline, slightly hygroscopic solid with slight odour.

M.P.: 179-181℃(decomp)

V.P.: Negligible

Solubility. In water c. 200g/1(25℃). Very slightly soluble in methanol and ethanol. Insoluble in acetone, diethyl ether, ethyl acetate, chloroform, benzene, and hexane

Stability: Stable in acidic conditions, but hydrolysed in neutral or alkaline media

 

Formulation types: DP; GR; SP

Biochemistry: Analogue or propesticide of the natural toxin nereistoxin. Nicotinergic acetylcholine blocker, causing paralysis by blocking cholinegic transmissions in the central nervous systems of insects

Mode of action: Systemic insecticide with stomach and contact action. Insects discontinue feeding, and die of starvation

Uses: Cartap hydrochloride is used, at c.a 0.4-1.0kg/ha, for control of chewing and sucking insects (particularly Lepidoptera and Coleoptera), at almost all stages of development, on many crops,including rice (Chilo suppressalis, Cnaphalocroclis, Lissorhoptrus oryzophilus and rice-leaf beetle), potatoes, cabbage and other vegetables(Agromyzidae,Leptinotarsa decemlineata and Plutella xylostella); also on soya beanuts, sunflowers, maize, sugar beet, wheat , pearley, pome fruit, stone fruit, citrus fruit, vines, chestnuts,ginger, tea, cotton, and sugar cane

Phytotoxicity: May be phytotoxic to cotton, tobacco, and apples, under certain soil and climatic conditions

Compatibility: Not compatible with pesticides which are alkaline

 

Reviews: FAO/WHO 74 see part 2 of the Bibliography.

Oral: Acute oral LD₅₀ for male rats 345, female rats 325, male mice 150, fernale mice 154 mg/kg.

Skin and eye: Acute percutaneous LB₅₀ for mice >1000 mg/kg: no irritation to skin or eyes in rabbits.

Inhalation: LC₅₀ (6 h) for rats >0.54 mg/l.

Noel:  (2 y) for rats 10 mg/kg b.w. daily; (1.5 y) for mice 20 mg/kg b.w. daily.

ADI: (JMPR) ADI withdrawn [1995]. |[cartap]

Toxicity: WHO (a.i.) II; EPA (formulation) II

EC hazard: Xn; R21/22

 

Fish: LC₅₀ for carp 1.6 mg/l (24 h) and 1.0 mg/l (48 h).
Other aquatic spp. LC₅₀ (24 h) for Moina macrocopa 12.5-25 mg/l.

Worms: /Bees: Moderately toxic to honeybees.

 

Animals: EHC 76 (WHO, 1988).
In rats, the carbonyl carbon is hydrolysed, and the sulfur oxidised, with N demethylation of thiomethyl derivatives. No accumulation occurs in tissues. Rapidly excreted in the urine.

Soil/Environment: DT₅₀ in soil c. 3 d