Common name: Acetamiprid

Other name: Acetamiprid (pa ISO)

Iupac name: (E)-N1-[（6-chloro-3-pyridyl）methyl]-N2-cyano- N1-methylacetamidine

Chemical abstracts name:(E)-N-[（6-chloro-3-pyridyl）methyl]-N′-cyano- N-methylacetamidine

Type:Insecticide for Agriculture

CAS RN:[135410-20-7]

 

M.F.: C₁₀H₁₁ClN₄

S.F.:       

Mol Wt:222.7

 

Form (appearance):       Colourless crystals

M.P.:98.9℃

V.P.:<1×10-3 mPa (25℃)

S.G.:1.330 (20℃)

Solubility.:   In water 4250 mg/l (25℃). Soluble in acetone, methanol, ethanol, dichloromethane, chloroform, acetonitrile and tetrahydrofuran

Stability:   Stable in buffered solutions at pH 4,5,7. Degraded slowly at pH 9 and 45℃. Stable under sunlight

Henry:< 5.3×10-8 Pa m3 mol-1(calc)

KowlogP:0.80 (25℃)

 

Formulation types:FU;GR;EC;WP

Biochemistry:    Agonist of the nicotinic acetylcholine receptor, affecting the synapses in the insect central nervous system

Mode of action:Systemic insecticide with translaminar activity and with contact and stomach action

Uses:Control of Hemiptera, especially aphids, Thysanoptera and Lepidoptera, by soil and foliar application, on a wide range of crops, especially vegetables, fruit and tea. Applied at 75-300 g/ha on vegetables, 100-700 g/ha in orchards

 

Oral:Acute oral LD₅₀ for male rats 217, female rats 146, mate mice 198, female mice 184 mg/kg.

Skin and eye: Acute percutaneous LD₅₀for male and female rats >2000 mg/kg. Non-irritating to skin and eyes (rabbits); not a skin sensitiser (guinea pigs).

Inhalation:LC₅₀ (4 h) for male and female rats >0.29 mg/l.

Noel:(2 y) for rats 7.1 mg/kg b.w.; (18 mo) for mice 20.3 mg/kg b.w.; (1 y) for dogs 20 mg/kg b.w.

/Other Negative in the Ames test.

 

Birds:LD₅₀for bobwhite quail 180 mg/k8. LC50 for bobwhite quail >5000 ppm.

Fish:LC₅₀ (24-96 h) for carp >100 mg/l.

Daphnia:LC₅₀ (24 h) >200 mg/l.

Algae:EC₅₀ (72 h) >98.3 mg/l; NOEC (72 h) 98.3 mg/l.

 

Plant:Slowly degraded on or in plants, forming five identified metabolites (H. Saito et al., Proc. 9th IUPAC Intl Congr: Pestic. Chem., London, 1998, 2, 5A-010).

Soil/Environment:DT₅₀ in clay loam 1 d; in light clay 1-2 d. DT₅₀for total residues 15-30 d.